Preimplantation Genetic Testing in Mumbai

Pre-Implantation Genetic testing

Reproductive Endocrinology & Fertility (CREF)

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Preimplantation genetic testing (PGT) is a technique used to identify chromosomal genetic abnormalities in embryos created through in vitro fertilization (IVF / ICSI ) before pregnancy. The term "preimplantation genetic testing" refers to the evaluation of embryos before implantation or pregnancy.

  • Couples who have had a previous pregnancy with aneuploidy
  • Women who have had two or more miscarriages ( Recurrent pregnancy loss )
  • Women who have experienced previously failed embryo implantation ( Recurrent Implantation Failure )
  • Women diagnosed with unexplained infertility
  • Women older than age 35
  • Positive History of Chromosomal abnormalities in the Family.
  • Pre-implantation Testing for Monogenic disorders ( PGT-M )
    This technique is used to test the embryos for ( A ) Single Gene Disorders ( B ) Hereditary Cancer Syndromes.
  • Pre-implantation Testing for Structural Rearrangements ( PGT- SR)
    This Technique is used to test embryos that are at risk for chromosome gains and losses related to parental structural chromosomal abnormalities (eg translocations, inversions, deletions, and insertions).
  • Pre-implantation Testing for Aneuploidy ( PGT- A)
    This technique is used to test for whole chromosome abnormalities.
  • How is Pre-Implantation Testing performed
    There are 2 steps for performing the PGT on embryos derived through IVF / ICSI.
    • Embryo biopsy of Day 5 embryos ( Blastocyst ). A few cells ( 5-10 cells ) are removed from the trophectoderm. The cells that are determined to form a baby are not disturbed.
    • Analysis of the Biopsy material by a Genetic Lab. The results are usually available in 10-15 days.